Raj at 10:09, 11 January 2013

2013-01-11T10:09:28Z

← Older revision		Revision as of 10:09, 11 January 2013
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	**Alleles of more complexity will be more suceptible to mutation		**Alleles of more complexity will be more suceptible to mutation
	*Genome size is inversely correlated with silent site mutation		*Genome size is inversely correlated with silent site mutation
	[[Category:Readings]]		[[:Category:Readings]]

Raj at 19:19, 3 January 2010

2010-01-03T19:19:08Z

← Older revision		Revision as of 19:19, 3 January 2010
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	**Alleles of more complexity will be more suceptible to mutation		**Alleles of more complexity will be more suceptible to mutation
	*Genome size is inversely correlated with silent site mutation		*Genome size is inversely correlated with silent site mutation
			[[Category:Readings]]

Raj: New page: * Genetic Drift It is basically random sampling of alleles in the subsequent generation Using a mathematical model, it has been show that an average of 4N generations (N = population ...

2008-08-24T03:15:38Z

New page: * Genetic Drift **It is basically random sampling of alleles in the subsequent generation **Using a mathematical model, it has been show that an average of 4N generations (N = population ...

New page

* Genetic Drift
**It is basically random sampling of alleles in the subsequent generation
**Using a mathematical model, it has been show that an average of 4N generations (N = population size) are required for an allele to get fixed in that population
**Infinite Mutaion model (measure of increase of allels) and Stepwise mutation model (in/decrease of alleles in a pop),. often used to measure the loss of allles (Drift) in a population
*Importance of linkage
**Linkage plays an impo role. Deleterious genes are selected in linked status, while lost in unlinked status
*Genetic Draft
** Reduced efficiency of selection on a linked loci=> Hill-Robertson Effect
** Selective sweep (or hitchhiking effect) is the reduction or elimination of variation among the nucleotides in neighbouring DNA of a mutation as the result of recent and strong natural selection.
** Effective population size: is the inbreeding effective pop size
** Relationship between effective and actual size: They are proportional, but effective pop size gets reduced with more of selective sweeps
*Population size:
** Pop size inversely proportionate to to the body size
*Higher Mutation rates:
** Genome size is +vely correlated with the base-substitution rate
** Genome size is -vely correlated with the recombination rate
*Effective pop size:
** Within species allelic diversity (basically the subtitutions per silent site) is more in prokaryotes (more pop size and less genome size) compared to vertibrates
*Sources of Bias:
**Nucleotide heterozygosity
**Mutation
**Mismatch repair mechanisms
*Resolution of Paradox variation
**EPS vary between larger and smallest organisms atleast to 5 order
*Mutationas a Weak selective force
**Alleles of more complexity will be more suceptible to mutation
*Genome size is inversely correlated with silent site mutation

Pop Size Matters - Revision history

Raj at 10:09, 11 January 2013

Raj at 19:19, 3 January 2010

Raj: New page: * Genetic Drift **It is basically random sampling of alleles in the subsequent generation **Using a mathematical model, it has been show that an average of 4N generations (N = population ...

Raj: New page: * Genetic Drift It is basically random sampling of alleles in the subsequent generation Using a mathematical model, it has been show that an average of 4N generations (N = population ...